Detalhe da pesquisa
1.
mRNA vaccine against malaria tailored for liver-resident memory T cells.
Nat Immunol
; 24(9): 1487-1498, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37474653
2.
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides.
Nat Chem Biol
; 20(2): 251-260, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996631
3.
NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation.
Nat Methods
; 19(2): 205-215, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35132245
4.
The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity.
Int J Mol Sci
; 24(7)2023 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37047605
5.
Skyllamycins D and E, Non-Ribosomal Cyclic Depsipeptides from Lichen-Sourced Streptomyces anulatus.
J Nat Prod
; 84(9): 2536-2543, 2021 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34490774
6.
Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui.
J Nat Prod
; 84(2): 544-547, 2021 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33496582
7.
Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug.
Biotechnol Lett
; 43(1): 203-211, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32851465
8.
The indigoidine synthetase BpsA provides a colorimetric ATP assay that can be adapted to quantify the substrate preferences of other NRPS enzymes.
Biotechnol Lett
; 42(12): 2665-2671, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32681380
9.
High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor.
Molecules
; 25(20)2020 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33066278
10.
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy.
Biochemistry
; 58(35): 3700-3710, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31403283
11.
Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum.
J Nat Prod
; 82(7): 2000-2008, 2019 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31306000
12.
A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation.
Biotechnol Lett
; 41(10): 1155-1162, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31392514
13.
Secondary metabolism in the lichen symbiosis.
Chem Soc Rev
; 47(5): 1730-1760, 2018 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29094129
14.
Structural, functional and evolutionary perspectives on effective re-engineering of non-ribosomal peptide synthetase assembly lines.
Nat Prod Rep
; 35(11): 1210-1228, 2018 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30069573
15.
Integrated activities of two alternative sigma factors coordinate iron acquisition and uptake by Pseudomonas aeruginosa.
Mol Microbiol
; 106(6): 891-904, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28971540
16.
Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation.
Biotechnol Lett
; 40(2): 359-367, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29147875
17.
Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step.
Molecules
; 23(7)2018 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29987261
18.
Reduction of quinones and nitroaromatic compounds by Escherichia coli nitroreductase A (NfsA): Characterization of kinetics and substrate specificity.
Arch Biochem Biophys
; 614: 14-22, 2017 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27986535
19.
Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.
Biochem J
; 471(2): 131-53, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26431849
20.
Portability of the thiolation domain in recombinant pyoverdine non-ribosomal peptide synthetases.
BMC Microbiol
; 15: 162, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26268580